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Sustained Immunological Responses to Highly Active Antiretroviral Therapy at 36 Months in a Ghanaian HIV Cohort

Lookup NU author(s): Dr Ulrich Schwab

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Abstract

Two hundred thirty-seven Ghanaian human immunodeficiency virus-infected patients who were starting antiretroviral therapy underwent clinical and immunological monitoring for 3 years. Seventy-eight percent of patients had disease classified as World Health Organization stage III or IV. The mean increase in the CD4 cell count was 395 cells/mm(3), 13% of patients experienced immunological failure, and 8% of patients switched treatment to a second-line regimen. However, two-thirds of patients who experienced immunological failure did not switch treatment, and 31% of all patients were lost to follow-up.

Publication metadata

Author(s): Collini P, Schwab U, Sarfo S, Obeng-Baah J, Norman B, Chadwick D, Bibby D, Bedu-Addo G

Publication type: Article

Publication status: Published

Journal: Clinical Infectious Diseases

Year: 2009

Volume: 48

Issue: 7

Pages: 988-991

ISSN (print): 1058-4838

ISSN (electronic): 1537-6591

Publisher: University of Chicago Press

URL: http://dx.doi.org/10.1086/597353

DOI: 10.1086/597353

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