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Lookup NU author(s): Dr Jolanta Weaver
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Obesity is associated with several endocrine diseases, including common ones such as hypothyroidism and polycystic ovarian syndrome to rare ones such as Cushing's syndrome, central hypothyroidism and hypothalamic disorders. The mechanisms for the development of obesity vary in according to the endocrine condition. Hypothyroidism is associated with accumulation of hyaluronic acid within various tissues, additional fluid retention due to reduced cardiac output and reduced thermogenesis. The pathophysiology of obesity associated with polycystic ovarian syndrome remains complex as obesity itself may simultaneously be the cause and the effect of the syndrome. Net excess of androgen appears to be pivotal in the development of central obesity. In Cushing's syndrome, an interaction with thyroid and growth hormones plays an important role in addition to an increased adipocyte differentiation and adipogenesis. This review also describes remaining rare cases: hypothalamic obesity due to central hypothyroidism and combined hormone deficiencies. Copyright (c) 2008 S. Karger AG, Basel.
Author(s): Weaver JU
Editor(s): Korbonits M
Publication type: Book Chapter
Publication status: Published
Book Title: Obesity and Metabolism
Print publication date: 01/01/2008
Series Title: Frontiers of Hormone Research
Place Published: Basel, Switzerland
Notes: e-ISBN: 978-3-8055-8430-2
Library holdings: Search Newcastle University Library for this item