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Classical endocrine diseases causing obesity

Lookup NU author(s): Dr Jolanta Weaver


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Obesity is associated with several endocrine diseases, including common ones such as hypothyroidism and polycystic ovarian syndrome to rare ones such as Cushing's syndrome, central hypothyroidism and hypothalamic disorders. The mechanisms for the development of obesity vary in according to the endocrine condition. Hypothyroidism is associated with accumulation of hyaluronic acid within various tissues, additional fluid retention due to reduced cardiac output and reduced thermogenesis. The pathophysiology of obesity associated with polycystic ovarian syndrome remains complex as obesity itself may simultaneously be the cause and the effect of the syndrome. Net excess of androgen appears to be pivotal in the development of central obesity. In Cushing's syndrome, an interaction with thyroid and growth hormones plays an important role in addition to an increased adipocyte differentiation and adipogenesis. This review also describes remaining rare cases: hypothalamic obesity due to central hypothyroidism and combined hormone deficiencies. Copyright (c) 2008 S. Karger AG, Basel.

Publication metadata

Author(s): Weaver JU

Editor(s): Korbonits M

Publication type: Book Chapter

Publication status: Published

Book Title: Obesity and Metabolism

Year: 2008

Volume: 36

Pages: 212-228

Print publication date: 01/01/2008

Series Title: Frontiers of Hormone Research

Publisher: Karger

Place Published: Basel, Switzerland

Notes: e-ISBN: 978-3-8055-8430-2

Library holdings: Search Newcastle University Library for this item

ISBN: 9783805584296


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