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Parkinson Disease With Dementia Comparing Patients With and Without Alzheimer Pathology

Lookup NU author(s): Dr Iryna Ziabreva, Emeritus Professor Elaine Perry, Dr Clive Ballard, Dr Dag Aarsland


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Subjects with Parkinson disease (PD) frequently develop dementia with greater than one-third meeting neuropathologic diagnostic criteria for Alzheimer disease (AD). The objective is to identify clinical and neuropathologic differences between Parkinson disease with dementia (PDD) subjects, with and without coexistent AD pathology. Neuropathologic examination was available on subjects diagnosed by clinicopathologic criteria with PDD - AD (N = 23) and PDD + AD (N = 28). A small subset of subjects with PDD - AD and PDD + AD had received at least 1 standardized neuropsychologic assessment. PDD + AD subjects were significantly older at age of PD onset and death, progressed to onset of dementia in less time, and had a shorter duration of PD symptoms before the onset of dementia. Education, responsiveness Of L-dopa and dopaminergic medications, presence of cognitive fluctuations and hallucinations, and mean Mini-Mental State Examination, Global Deterioration Scale, Functional Assessment Staging, and Unified Parkinson Disease Rating Scale scores did not differ significantly between the 2 groups. The PDD + AD group had significantly greater total plaques, neuritic plaques, total tangles, and Braak stages compared with PDD - AD. This study suggests that it is difficult to distinguish PDD + AD and PDD - AD on the basis of movement, clinical, and neuropsychologic assessment. PDD - AD and PDD + AD have similar degrees of dementia and approximately half of PDD subjects have enough AD pathology to attain a neuropathologic diagnosis of AD. PDD can develop in the absence of significant Alzheimer pathology.

Publication metadata

Author(s): Sabbagh MN, Adler CH, Lahti TJ, Connor DJ, Vedders L, Peterson LK, Caviness JN, Shill HA, Sue LI, Ziabreva I, Perry E, Ballard CG, Aarsland D, Walker DG, Beach TG

Publication type: Article

Publication status: Published

Journal: Alzheimer Disease and Associated Disorders

Year: 2009

Volume: 23

Issue: 3

Pages: 295-297

ISSN (print): 0893-0341

ISSN (electronic): 1546-4156

Publisher: Lippincott Williams & Wilkins


DOI: 10.1097/WAD.0b013e31819c5ef4


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Funder referenceFunder name
Sun Health Research Institute Brain Donation Program
Arizona Parkinson's Disease Consortium
Michael J. Fox Foundation for Parkinson's Research (The Prescott Family Initiative)
0011Arizona Biomedical Research Commission
05-901Arizona Biomedical Research Commission
4001Arizona Biomedical Research Commission
P30 AG19610National Institute on Aging