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Lookup NU author(s): Dr Steve Parry,
Professor Julia Newton
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Objective: to investigate the potential for impedance cardiography (ICG)-derived haemodynamic measures to predict HUT test outcome in unexplained syncope. Design: prospective controlled study. Subjects: eighty-six patients with unexplained syncope and 43 non-syncopal controls. Methods: all subjects underwent continuous heart rate, blood pressure and ICG measurements during 10 min supine rest and during HUT. Vasovagal syncope was diagnosed when patients experienced symptom reproduction with concomitant haemodynamic derangements. Results: during rest prior to HUT, the syncopal group had higher mean heart rate (P = 0.0008) and lower baroreceptor effectiveness index (P 3.5, EDI > 77, LVWI > 4.7) with 93% sensitivity and 17% specificity. Conclusion: supine haemodynamic measures derived from transthoracic ICG can simply, non-invasively and sensitively differentiate HUT-positive patients from those with negative tilt tests. Further work is needed, particularly in older patients, before this technique can be used in clinical practice.
Author(s): Parry SW, Norton M, Pairman J, Baptist M, Wilton K, Reeve P, Sutcliffe K, Newton JL
Publication type: Article
Publication status: Published
Journal: Age and Ageing
ISSN (print): 0002-0729
ISSN (electronic): 1468-2834
Publisher: Oxford University Press
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