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Pathogenesis of thrombotic microangiopathy: insights from animal models

Lookup NU author(s): Dr Anna Richards, Professor David KavanaghORCiD

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Abstract

Animal models are important experimental tools for investigating the molecular mechanisms, environmental and genetic susceptibilities underlying the development of thrombotic microangiopathies. Large mammal, small animal models, knockout, transgenic and conditional knockout mouse models are available to investigate haemolytic uraemic syndrome, thrombotic thrombocytopenic purpura and vascular endothelial growth factor-associated thrombotic microangiopathy. These models have shown that it is possible to model the human conditions. However, differences in human and rodent physiology mean that caution is required when interpreting the findings. These models offer realistic prospects for identifying and testing novel therapeutic strategies in a range of thrombotic microangiopathies prior to human trials

Publication metadata

Author(s): Richards A, Kavanagh D

Publication type: Article

Publication status: Published

Journal: Nephron Experimental Nephrology

Year: 2009

Volume: 113

Issue: 4

Pages: e97-e103

ISSN (print): 1660-2129

ISSN (electronic): 1660-8151

Publisher: S. Karger AG

URL: http://dx.doi.org/10.1159/000235253

DOI: 10.1159/000235253

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