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Reactions of Pd(II) with Chelate-Tethered 2,6-Diaminopurine Derivatives: N3-Coordination and Reaction of the Purine System

Lookup NU author(s): David Amantia, Emeritus Professor Bill CleggORCiD, Dr Ross Harrington, Professor Andrew HoultonORCiD


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Alkyldiamine-tethered derivatives of 2,6-diaminopurine, ethylenediamine-N9-propyl-2,6-diaminopurine, L1, and ethylenediamine-N9-ethyl-2,6-diaminopurine, L2, react with Pd(II) to give N3-coordinated complexes, However, the exact nature of the resulting complex is dependent on the reaction conditions. With PdCl2(MeCN)(2) in MeCN/H2O the expected [PdCl(N3-2,6-DAP-alkyl-en)](+) complex, 1, is formed with L1 chelating the metal center in a tridentate manner through the diamine function and N3 of the purine base. However, under the same conditions the shorter, ethyl-tethered, L2 gives a complex dication, 2, containing a tetradentate ligand forming simultaneously 5-, 6-, and 7-membered chelate rings. This resulting acetamidine, derived by addition to coordinated MeCN, appears to be the first such case involving the 2-amino group of a purine. The ethyl-analogue of 1, [PdCl(N3-2,6-DAP-Et-en)(+) 3, was prepared by reaction of L2 with K2PdCl4 in aqueous media.

Publication metadata

Author(s): Galindo MA, Amantia D, Martinez-Martinez A, Clegg W, Harrington RW, Martinez VM, Houlton A

Publication type: Article

Publication status: Published

Journal: Inorganic Chemistry

Year: 2009

Volume: 48

Issue: 23

Pages: 11085-11091

ISSN (print): 0020-1669

ISSN (electronic): 1520-510X

Publisher: American Chemical Society


DOI: 10.1021/ic901475y


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