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Lookup NU author(s): Dr Richard Temperley, Ricarda Richter, Sven Dennerlein, Professor Robert Lightowlers, Professor Zofia Chrzanowska-LightowlersORCiD
Human mitochondria are not strict adherents to the universal genetic code, with modifications that include the apparent recoding of two arginine triplets to termination signals. This use of both AGA and AGG occurs rarely in other mammals, and this putative change has long posed a challenging conundrum. A –1 mitoribosome frameshift upstream of the rare codons would necessitate recognition of only the conventional UAA and UAG termination codons. By using a sequence-specific endoribonuclease, we show that the rare arginine codons, presumably in association with other cis elements, promote frameshifting in human mitoribosomes.
Author(s): Temperley R, Richter R, Dennerlein S, Lightowlers RN, Chrzanowska-Lightowlers ZM
Publication type: Article
Publication status: Published
Journal: Science
Year: 2010
Volume: 327
Issue: 5963
Pages: 301-301
Print publication date: 15/01/2010
Date deposited: 24/06/2010
ISSN (print): 0036-8075
ISSN (electronic): 1095-9203
Publisher: American Association for the Advancement of Science
URL: http://dx.doi.org/10.1126/science.1180674
DOI: 10.1126/science.1180674
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