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Covariance Tc-99m-Exametazime SPECT Patterns in Alzheimer's Disease and Dementia with Lewy Bodies: Utility in Differential Diagnosis

Lookup NU author(s): Dr Sean Colloby, Professor John-Paul TaylorORCiD, Dr Michael FirbankORCiD, Professor Ian McKeith, Professor David Williams, Professor John O'Brien


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Tc-99m-exametazime single photon emission computed tomography (SPECT) scans of 36 patients with Alzheimer's disease (AD) and 30 with dementia with Lewy bodies (DLB) underwent region of interest (ROI) and principal component analysis (PCA). Principal component analysis was performed on the entire ROI data set. Principal components (PCs) were obtained, representing common intercorrelated regions in AD and DLB. Topographic expression that signified the extent to which a participant expressed the topographic covariance pattern was derived and used as a discriminatory variable. Principal components were identified, accounting for 77% of total data variance. Significant (PC x group) interaction was observed (P < .001). Topographic expression was significantly higher in DLB than AD (F-1.64 - 21.6, P < .001), and differentiated DLB from AD with sensitivity 73% specificity 72%. Calculating the topographic expression in an independent data set of 48 patients with AD and 23 with DLB gave sensitivity 70%, specificity 67%. Principal component analysis captures additional sources of variance and if perfusion SPECT is the only scan available, this procedure may offer extra information.

Publication metadata

Author(s): Colloby SJ, Taylor JP, Firbank MJ, McKeith IG, Williams ED, O'Brien JT

Publication type: Article

Publication status: Published

Journal: Journal of Geriatric Psychiatry and Neurology

Year: 2010

Volume: 23

Issue: 1

Pages: 54-62

Print publication date: 01/03/2010

ISSN (print): 0891-9887

ISSN (electronic): 1552-5708

Publisher: Sage


DOI: 10.1177/0891988709355272


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Funder referenceFunder name
G9817682Medical Research Council UK