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Coupling genetics and post-genomic approaches to decipher the cellular splicing code at a systems-wide level

Lookup NU author(s): Professor David Elliott

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Abstract

Nuclear RNA processing is a critical stage in eukaryotic gene expression, and is controlled in part by the expression and concentration of nuclear RNA-binding proteins. Different nuclear RNA-binding proteins are differentially expressed in different cells, helping the spliceosome to decode pre-mRNAs into alternatively spliced mRNAs. Recent post-genomic technology has exposed the complexity of nuclear RNA processing, and is starting to reveal the mechanisms and rules through which networks of RNA-binding proteins can regulate multiple parallel pathways. identification of multiple parallel processing pathways regulated by nuclear RNA-binding proteins is leading to a systems-wide understanding of the rules and consequences of alternative nuclear RNA processing.

Publication metadata

Author(s): Liu YL, Elliott DJ

Publication type: Conference Proceedings (inc. Abstract)

Publication status: Published

Conference Name: Biochemical Society Transactions: 13th Tenovus Scotland Symposium - Gene Expression in Development and Disease

Year of Conference: 2010

Pages: 237-241

ISSN: 0300-5127

Publisher: Portland Press Ltd.

URL: http://dx.doi.org/10.1042/BST0380237

DOI: 10.1042/BST0380237

Library holdings: Search Newcastle University Library for this item

ISBN: 14708752

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