Toggle Main Menu Toggle Search

Open Access padlockePrints

Sugar transporters of the major facilitator superfamily in aphids; from gene prediction to functional characterization

Lookup NU author(s): Professor Angharad MR GatehouseORCiD


Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


Analysis of the pea aphid (Acyrthosiphon pisum) genome using signatures specific to the Major Facilitator Superfamily (Pfam Clan CL0015) and the Sugar_tr family (Pfam Family PF00083) has identified 54 genes encoding potential sugar transporters, of which 38 have corresponding ESTs. Twenty-nine genes contain the InterPro IPR003663 hexose transporter signature. The protein encoded by Ap_ST3, the most abundantly expressed sugar transporter gene, was functionally characterized by expression as a recombinant protein. Ap_ST3 acts as a low-affinity uniporter for fructose and glucose that does not depend on Na+ or H+ for activity. Ap_ST3 was expressed at elevated levels in distal gut tissue, consistent with a role in gut sugar transport. The A. pisum genome shows evidence of duplications of sugar transporter genes.

Publication metadata

Author(s): Price DRG, Tibbles K, Shigenobu S, Smertenko A, Russell CW, Douglas AE, Fitches E, Gatehouse AMR, Gatehouse JA

Publication type: Article

Publication status: Published

Journal: Insect Molecular Biology

Year: 2010

Volume: 19

Pages: 97-112

Print publication date: 01/03/2010

ISSN (print): 0962-1075

ISSN (electronic): 1365-2583

Publisher: Wiley-Blackwell Publishing Ltd.


DOI: 10.1111/j.1365-2583.2009.00918.x


Altmetrics provided by Altmetric


Funder referenceFunder name
Sarkaria Foundation
BB/E006280/1Biochemical and Biotechnological Sciences Research Council