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Congenital anomalies in children with cerebral palsy: a population-based record linkage study

Lookup NU author(s): Professor Judith Rankin, Emeritus Professor Allan ColverORCiD


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AIM Our aim was to determine the proportion of children with cerebral palsy(CP) who have a congenital anomaly (CA) in three regions (Isere Region, French Alps; Funen County, Denmark; Northern Region, England) where population-based CP and CA registries exist, and to classify the children according to CA subtype. METHOD Data for children born between 1991 and 1999 were linked using electronic matching of cases. All potential matches were checked manually by each centre and verified as true matches. RESULTS A total of 1104 children with CP were born during the study period (663 males, 441 females). Of these, 166 (15%; 95% Confidence Interval [CI] 13.0-17.3) children with CP had a CA: 8.8% had a cerebral anomaly, 4.8% had a non-cerebral anomaly, and 1.4% had a non-cerebral-related syndrome or a chromosomal/genetic anomaly. INTERPRETATION The prevalence of cerebral anomaly was highest in children with ataxic CP (41.7%) and lowest in those with dyskinetic CP (2.1%). Cerebral anomalies were found in 8.4% and 7% of children with bilateral and unilateral spastic CP respectively. The most frequent cerebral anomalies were primary microcephaly (26.5%) and congenital hydrocephalus (17.3%). The most common non-cerebral anomalies recorded were cardiac (12.6% of children with CP and CA), urinary (5.4%), and musculoskeletal (5.4%). The prevalence of cerebral anomalies was higher among children born at term (13%) than among those born preterm (3.8%). Associated sensorineural or intellectual impairments occurred more often in children with CP and cerebral anomalies. We concluded that cerebral and non-cerebral CA prevalence was higher among the CP population than in the general population of live births.

Publication metadata

Author(s): Rankin J, Cans C, Garne E, Colver A, Dolk H, Uldall P, Amar E, Krageloh-Mann I

Publication type: Article

Publication status: Published

Journal: Developmental Medicine and Child Neurology

Year: 2010

Volume: 52

Issue: 4

Pages: 345-351

ISSN (print): 0012-1622

ISSN (electronic): 1469-8749

Publisher: Mac Keith Press


DOI: 10.1111/j.1469-8749.2009.03415.x

PubMed id: 19737295


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Funder referenceFunder name
Department of Health Policy Research Programme ( Disease Register)
National Institute of Health Research ( Department of Health)
Danish Spastic Society
DG Sanco Public Health Programme
La Foundation Motrice
2003131DG Sanco