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Architecture of peptidoglycan: more data and more models

Lookup NU author(s): Professor Waldemar Vollmer


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Peptidoglycan forms a net-like sacculus made of glycan strands crosslinked by peptides. The length of the glycan strands and the degree of crosslinkage vary with bacterial species, strains and growth conditions. Several models for the three-dimensional architecture of peptidoglycan have been proposed, some of which have been tested experimentally. The new data support a layered model in Gram-negative bacteria, and a more elaborate peptidoglycan architecture, with bands made of coiled bundles of glycan strands, in the rod-shaped Bacillus subtilis. However, many questions remain unanswered and, therefore, more data and more models are required to decipher the complex cell wall architecture in bacteria.

Publication metadata

Author(s): Vollmer W, Seligman SJ

Publication type: Article

Publication status: Published

Journal: Trends in Microbiology

Year: 2010

Volume: 18

Issue: 2

Pages: 59-66

Print publication date: 01/02/2010

ISSN (print): 0966-842X

ISSN (electronic): 1878-4380

Publisher: Elsevier


DOI: 10.1016/j.tim.2009.12.004


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