Browse by author
Lookup NU author(s): Professor Maya Sieber-Blum
Full text for this publication is not currently held within this repository. Alternative links are provided below where available.
Here we show that stem cell factor (SCF) signaling through its receptor, c-kit, is essential for the development of c-kit-expressing small- and medium-diameter primary sensory neurons. We used the W mouse, which is c-kit deficient and has a perinatal lethal phenotype due to a naturally occurring point mutation in the c-kit gene. In c-kit-null newborn mice, 52.5% of substance P immunoreactive and 31.4% of calcitonin gene-related peptide (CGRP) immunoreactive small- and medium-diameter sensory neurons were absent, whereas large-diameter sensory neurons were unaffected. Equivalent deficits occurred during embryogenesis. There was neither a developmental delay nor degeneration of differentiated neurons. We thus conclude that, in the absence of SCF signaling, neural crest-derived progenitors do not differentiate into c-kit-expressing visceral and somatic afferent neurons.
Author(s): Zhang ZJ, Sieber-Blum M
Publication type: Article
Publication status: Published
Journal: Developmental Neuroscience
ISSN (print): 0378-5866
ISSN (electronic): 1421-9859
Publisher: S. Karger AG
Altmetrics provided by Altmetric