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Functional role of uterine natural killer (uNK) cells in human early pregnancy decidua

Lookup NU author(s): Dr Gendie Lash, Professor Steve RobsonORCiD, Dr Judith Bulmer


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Leukocytes comprise approximately 30-40% of decidual stromal cells in early human pregnancy. The major leukocyte component is the uterine natural killer (uNK) cells. Despite over 20 years of research the functional role of these cells in situ remains unknown although they have been proposed to play roles in immunotolerance, regulation of trophoblast invasion and remodeling of the spiral arteries. Herein we review the functional roles of this important decidual cell type. (C) 2010 Published by IFPA and Elsevier Ltd.

Publication metadata

Author(s): Lash GE, Robson SC, Bulmer JN


Publication type: Conference Proceedings (inc. Abstract)

Publication status: Published

Conference Name: Placenta: Annual Meeting of the International Federation of Placenta Associations

Year of Conference: 2010

Pages: S87-S92

ISSN: 0143-4004

Publisher: Elsevier Ltd


DOI: 10.1016/j.placenta.2009.12.022

Library holdings: Search Newcastle University Library for this item

ISBN: 15323102