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Treatment of primary angiitis of the central nervous system in childhood with mycophenolate mofetil

Lookup NU author(s): Dr Mario Abinun, Dr Rob ForsythORCiD, Dr Vankateswara Ramesh


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Objective. To assess the use of mycophenolate mofetil (MMF) in the treatment of refractory primary angiitis of the CNS in childhood (cPACNS). Methods. A retrospective chart review was performed in patients with cPACNS who were treated with MMF following failure of a combination of corticosteroids and another immunosuppressant. Results. Three patients from two centres were included in this study. The age of onset of disease was 5, 6 and 9 years. All the patients improved when treated with MMF, such that the dose of corticosteroids could be weaned or stopped. Conclusions. MMF should be considered for maintenance treatment in the management of patients with cPACNS refractory to the combination of corticosteroids and first-line immunosuppressive agents.

Publication metadata

Author(s): Sen ES, Leone V, Abinun M, Forsyth R, Ramesh V, Friswell M, O'Callaghan F, Ramanan AV

Publication type: Article

Publication status: Published

Journal: Rheumatology

Year: 2010

Volume: 49

Issue: 4

Pages: 806-811

Print publication date: 01/04/2010

ISSN (print): 1462-0324

ISSN (electronic): 1462-0332

Publisher: Oxford University Press


DOI: 10.1093/rheumatology/kep453


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