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Stress signalling to fungal stress-activated protein kinase pathways

Lookup NU author(s): Professor Brian Morgan, Professor Janet Quinn



The ability of microorganisms to survive and thrive within hostile environments depends on rapid and robust stress responses. Stress-activated protein kinase (SAPK) pathways are important stress-signalling modules found in all eukaryotes, including eukaryotic microorganisms such as fungi. These pathways consist of a SAPK that is activated by phosphorylation through a kinase cascade, and once activated, the SAPK phosphorylates a range of cytoplasmic and nuclear target substrates, which determine the appropriate response. However, despite their conservation in fungi, mechanisms that have evolved to relay stress signals to the SAPK module in different fungi have diverged significantly. Here, we present an overview of the diverse strategies used in the model yeasts Saccharomyces cerevisiae and Schizosaccharomyces pombe, and the pathogenic fungus Candida albicans, to sense and transduce stress signals to their respective SAPKs.

Publication metadata

Author(s): Smith DA, Morgan BA, Quinn J

Publication type: Review

Publication status: Published

Journal: FEMS Microbiology Letters

Year: 2010

Volume: 306

Issue: 1

Pages: 1-8

Print publication date: 01/05/2010

ISSN (print): 0378-1097

ISSN (electronic): 1574-6968



DOI: 10.1111/j.1574-6968.2010.01937.x