Browse by author
Lookup NU author(s): Fotios Drenos, Emeritus Professor Thomas Kirkwood
It is often claimed that genes affecting health in old age, such as cardiovascular and Alzheimer diseases, are beyond the reach of natural selection. We show in a simulation study based on known genetic (apolipoprotein E) and non-genetic risk factors (gender, diet, smoking, alcohol, exercise) that, because there is a statistical distribution of ages at which these genes exert their influence on morbidity and mortality, the effects of selection are in fact non-negligible. A gradual increase with each generation of the epsilon 2 and epsilon 3 alleles of the gene at the expense of the epsilon 4 allele was predicted from the model. The epsilon 2 allele frequency was found to increase slightly more rapidly than that for epsilon 3, although there was no statistically significant difference between the two. Our result may explain the recent evolutionary history of the epsilon 2, 3 and 4 alleles of the apolipoprotein E gene and has wider relevance for genes affecting human longevity.
Author(s): Drenos F, Kirkwood TBL
Publication type: Article
Publication status: Published
Journal: PLoS One
Year: 2010
Volume: 5
Issue: 3
Print publication date: 01/04/2010
Date deposited: 21/05/2010
ISSN (print):
ISSN (electronic): 1932-6203
Publisher: Public Library of Science
URL: http://dx.doi.org/10.1371/journal.pone.0010022
DOI: 10.1371/journal.pone.0010022
Altmetrics provided by Altmetric