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A comparative study to screen dementia and APOE genotypes in an ageing East African population

Lookup NU author(s): Professor Raj Kalaria


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Previous studies have established cross-cultural methods to screen for ageing-related dementia and susceptibility genes, in particular Alzheimer's disease (AD) among the Canadian Cree, African Americans and Yoruba in Nigeria. We determined whether the Community Screening Interview for Dementia (CSID), translated into Kikuyu, a major language of Kenya, could be used to evaluate dementia of the Alzheimer type. Using two sets of coefficients of cognitive and informant scores, two discriminant function (DF) scores were calculated for each of 100 elderly (>65 years) Nyeri Kenyans. When the cut-off points were selected for 100% sensitivities, the specificities of the DF scores were remarkably similar (93.75%) in the Kenyan sample. We propose the adapted CSID can be utilised to detect dementia among East Africans. We also show that apolipoprotein E epsilon 4 allele frequencies were high (similar to 30%) and not different between normal subjects and those with probable AD. There was no evidence to suggest years of education or vascular factors were associated with dementia status. (C) 2008 Elsevier Inc. All rights reserved.

Publication metadata

Author(s): Chen CH, Mizuno T, Elston R, Kariuki MM, Hall K, Unverzagt F, Hendrie H, Gatere S, Kioy P, Patel NB, Friedland RP, Kalaria RN

Publication type: Article

Publication status: Published

Journal: Neurobiology of Aging

Year: 2010

Volume: 31

Issue: 5

Pages: 732-740

Print publication date: 01/05/2010

ISSN (print): 0197-4580

ISSN (electronic): 1558-1497

Publisher: Elsevier


DOI: 10.1016/j.neurobiolaging.2008.06.014


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Funder referenceFunder name
Alzheimer's Association, USA
Joseph and Florence Mandel Foundation
Medical Research Council, UK
Nickman Family of Cleveland, Ohio
Institute for the Study of Aging, New York
1UO1 AG 17173-01A2National Institute on Aging
GM28356National Institute of General Medical Sciences
P30 AG 10133National Institute on Aging
P50 AG 08012Alzheimer's Disease Research Center Program
RO1 AG 09956National Institute on Aging
RR03655National Center for Research Resources