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Subclinical thyroid disorders: significance and clinical impact

Lookup NU author(s): Dr Salman Razvi, Dr Jolanta Weaver, Professor Simon PearceORCiD



Subclinical thyroid diseases are defined by abnormal serum thyroid stimulating hormone (TSH) levels associated with normal thyroid hormone concentrations. The diagnosis of these conditions depends on defining the 'normal' euthyroid TSH range; in this review, arguments for and against lowering the upper limit of TSH are summarised. Although, subclinical hypothyroidism and subclinical hyperthyroidism are frequently encountered, their long-term consequences are debated due to conflicting results from many observational studies. The causes, effects and outcomes of treatment of both subclinical diseases are described, and the direction of future research in these conditions is outlined.

Publication metadata

Author(s): Razvi S, Weaver JU, Pearce SHS

Publication type: Article

Publication status: Published

Journal: Journal of Clinical Pathology

Year: 2010

Volume: 63

Issue: 5

Pages: 379-386

Date deposited: 21/06/2010

ISSN (print): 0021-9746

ISSN (electronic): 1472-4146

Publisher: BMJ Group


DOI: 10.1136/jcp.2008.057414


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Funder referenceFunder name
G0500783Medical Research Council