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Immunohistochemical expression of basement membrane proteins of verrucous carcinoma of the oral mucosa

Lookup NU author(s): Professor Marco Carrozzo


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Squamous cell carcinoma (SCC) of the oral cavity is an extremely invasive tumour of stratified squamous epithelium that spreads throughout degradation of the basement membrane (BM) and extra-cellular matrix. Oral verrucous carcinoma (VC) is a rare low-grade variant of oral SCC that penetrates into the subepithelial connective tissue. It also has a different clinical behaviour from classical oral SCC. We investigated the immunohistochemical expression of laminin, laminin-5, collagen IV and fibronectin in VC, severe epithelial dysplasia (SED) and SCC in order to analyse if the patter of these molecules expression contributes to the differences in the biological behaviour of these diseases. The staining pattern of laminin was less intensive in SCC compared with SED and VC, and collagen IV expression was increased in VC compared with SED. Discontinuities of laminin, collagen IV and fibronectin were more evident in SED than in VC. This study indicates that VC has a biological behaviour different from SED or SCC, observable by immunohistochemistry in the BM zone.

Publication metadata

Author(s): Arduino PG, Carrozzo M, Pagano M, Broccoletti R, Scully C, Gandolfo S

Publication type: Article

Publication status: Published

Journal: Clinical Oral Investigations

Year: 2010

Volume: 14

Issue: 3

Pages: 297-302

ISSN (print): 1432-6981

ISSN (electronic): 1436-3771

Publisher: Springer


DOI: 10.1007/s00784-009-0296-y


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