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Lookup NU author(s): Sara Payne,
Dr Celine Cano,
Professor Bernard Golding,
Dr Ian Hardcastle,
Professor Roger Griffin
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Replacement of the core heterocycle of a defined series of chromen-4-one DNA-PK inhibitors by the isomeric chromen-2-one (coumarin) and isochromen-1-one (isocoumarin) scaffolds was investigated. Structure-activity relationships for DNA-PK inhibition were broadly consistent, albeit with a reduction of potency compared with the parent chromenone. (C) 2010 Elsevier Ltd. All rights reserved.
Author(s): Payne SL, Rodriguez-Aristegui S, Bardos J, Cano C, Golding BT, Hardcastle IR, Peacock M, Parveen N, Griffin RJ
Publication type: Article
Publication status: Published
Journal: Bioorganic & Medicinal Chemistry Letters
Print publication date: 14/05/2010
ISSN (print): 0960-894X
ISSN (electronic): 1464-3405
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