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Some appetitive procedures for examining associative learning in the mouse: Implications for psychopathology

Lookup NU author(s): Dr Domhnall Jennings


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There are few demonstrations of basic associative learning phenomena using appetitive procedures in mice. This article describes procedures for obtaining four associative learning phenomena in mice, using an appetitive conditioning procedure in which the reinforcer was delivery of a sucrose pellet, and the conditioned response head entry into the food tray. Experiment 1 demonstrated latent inhibition in a within-subjects procedure. Experiment 2 demonstrates both overshadowing and blocking, and Experiment 3 Pavlovian conditioned inhibition, which was evaluated by both summation and retardation tests. These procedures all have potential relevance to current translational research questions. The specific advantages of using appetitive tasks are discussed. (C) 2010 Elsevier B.V. All rights reserved.

Publication metadata

Author(s): Bonardi C, Bartle C, Bowles K, de Pulford F, Jennings DJ

Publication type: Article

Publication status: Published

Journal: Behavioural Brain Research

Year: 2010

Volume: 211

Issue: 2

Pages: 240-247

Print publication date: 01/08/2010

Date deposited: 19/07/2010

ISSN (print): 0166-4328

ISSN (electronic): 1872-7549

Publisher: Elsevier


DOI: 10.1016/j.bbr.2010.03.047


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