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The use of propofol and sevoflurane for surgical anaesthesia in New Zealand White rabbits

Lookup NU author(s): Dr Matthew Leach, Emeritus Professor Paul FlecknellORCiD


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New Zealand White (NZW) rabbits (n = 34) received intravenous propofol (16 +/- 5 mg/kg) for induction of anaesthesia followed by maintenance with sevoflurane (4.0 +/- 0.5%) in oxygen. All animals underwent ovariohysterectomy. Heart rate, respiratory rate, haemoglobin oxygen saturation, end-tidal carbon dioxide concentration, end-tidal sevoflurane concentration and oesophageal temperature were monitored every 5 min. Time from induction of anaesthesia to tracheal extubation and sternal recumbency were recorded as was the quality of recovery. Direct arterial blood pressure values (mmHg) were recorded every 5 min from 19 rabbits and 22 arterial blood gases analyses were performed (11 postintubation and 11 at the time of recovery). Propofol produced smooth induction of anaesthesia without production of apnoea. Intubation was successfully performed in all but one rabbit in an average of 4 +/- 3 min from the beginning of propofol administration. No ventilatory support was required during the anaesthetic period. Respiratory rate averaged 51 +/- 8 bpm and end-tidal CO2 (kPa) was 4.0 +/- 0.5 mmHg during anaesthesia. Blood gas values were maintained within normal limits and average mean arterial blood pressure was 73.4 +/- 7.9 mmHg. Time to regain the swallowing reflex following discontinuation of sevoflurane was 2 +/- 1 min and time to sternal recumbency was 8 +/- 0.3 min. No anaesthetic-related mortality occurred and all animals recovered uneventfully. Propofolsevoflurane anaesthesia produced a good quality of surgical anaesthesia for ovariohysterectomy and stable cardiopulmonary conditions. Propofol-sevoflurane anaesthesia in young healthy NZW rabbits appears to be an effective and practically useful method of anaesthesia.

Publication metadata

Author(s): Allweiler S, Leach MC, Flecknell PA

Publication type: Article

Publication status: Published

Journal: Laboratory Animals

Year: 2010

Volume: 44

Issue: 2

Pages: 113-117

Print publication date: 01/04/2010

ISSN (print): 0023-6772

ISSN (electronic): 1758-1117

Publisher: Royal Society of Medicine Press Ltd.


DOI: 10.1258/la.2009.009036


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