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Lookup NU author(s): Professor Mushtaq Saleem, Dr Richard WilkinsORCiD
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The overall activity and body comportment distribution of a wide range of cytoplasmic and lysosomal proteolytic enzymes was determined in the adults of American cockroach, Periplaneta americana. Individual proteolytic enzymes showed different overall and relative levels of activity in head, thorax, abdomen, leg, internal leg muscle and gut. The gut showed highest activities of alanyl aminopeptidase, dipeptidyl aminopeptidase (DAP) I, II and IV, and cathepsin B, L and H while head showed highest activities of arginyl, leucyl and tripeptidyl aminopeptidase. In vivo effects of lambda-cyhalothrin on proteases of various body compartments showed that almost all proteases in the gut, except cathepsin B, showed considerably elevated levels ranging from 19% in the case of proline endopeptidase and 429% in the case of DAP I. All DAPs manifested highest levels i.e. DAP I by 429%, DAP II by 355% and DAP IV by 178%, followed by cathepsin L (246%), cathepsin D (123%), tripeptidyl aminopeptidase (109%), arginyl aminopeptidase (78%), alanyl aminopeptidase (72%), leucyl aminopeptidase (49%), cathepsin H (37%) and proline endopeptidase (19%). Proteases of all other body compartments exhibited mixed responses, although in head and thorax, all cytoplasmic proteases were increased while almost all lysosomal proteases were decreased,
Author(s): Saleem MA, Wilkins RM, Shakoori AR
Publication type: Article
Publication status: Published
Journal: Pakistan Journal of Zoology
Year: 2010
Volume: 42
Issue: 5
Pages: 603-610
Print publication date: 01/10/2010
ISSN (print): 0030-9923
ISSN (electronic):
Publisher: Zoological Society of Pakistan
