Browse by author
Lookup NU author(s): Amit Patel, Andrew Bryant, Dr Heather Dickinson
Full text for this publication is not currently held within this repository. Alternative links are provided below where available.
Background Most women with advanced epithelial ovarian cancer will ultimately develop recurrent disease after completion of initial treatment with primary surgery and adjuvant chemotherapy. Secondary cytoreductive surgery may have survival benefits in selected patients. However, a number of chemotherapeutic agents are active in recurrent ovarian cancer and the standard treatment of patients with recurrent ovarian cancer remains poorly defined. Objectives To evaluate the effectiveness and safety of secondary surgical cytoreduction and chemotherapy compared to chemotherapy alone for women with recurrent epithelial ovarian cancer. Search strategy We searched the Cochrane Gynaecological Cancer Group Trials Register, The Cochrane Register of Controlled Trials, ( CENTRAL) Issue 1 2009, MEDLINE and EMBASE up to February 2009. We also searched registers of clinical trials, abstracts of scientific meetings, reference lists of review articles and contacted experts in the field. Selection criteria We searched for RCTs, quasi-randomised trials and non-randomised studies that compared secondary cytoreductive surgery and chemotherapy to chemotherapy alonein women with recurrent epithelial ovarian cancer. Data collection and analysis Three reviewers independently assessed whether potentially relevant studies met the inclusion criteria. No trials were found and therefore no data were analysed. Main results The search strategy identified 1431 unique references of which all were excluded on the basis of title and abstract. Author's conclusions We found no evidence from RCTs to inform decisions about secondary surgical cytoreduction and chemotherapy compared to chemotherapy alone for women with recurrent epithelial ovarian cancer. Ideally, a large randomised controlled trial or, at the very least, well designed non-randomised
Author(s): Galaal K, Naik R, Bristow RE, Patel A, Bryant A, Dickinson HO
Publication type: Review
Publication status: Published
Journal: Cochrane Database of Systematic Reviews
Year: 2010
Issue: 6
Pages: CD007822
Print publication date: 16/06/2010
ISSN (electronic): 1469-493X
URL: http://dx.doi.org/10.1002/14651858.CD007822.pub2
DOI: 10.1002/14651858.CD007822.pub2
