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Lookup NU author(s): Emeritus Professor Doug Turnbull
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From their very beginning to the present day, mitochondria have evolved to become a crucial organelle within the cell. The mitochondrial genome encodes only 37 genes, but its compact structure and minimal redundancy results in mutations on the mitochondrial genome being an important cause of genetic disease. In the present chapter we describe the up-to-date knowledge about mitochondrial DNA structure and function, and describe some of the consequences of defective function including disease and aging.
Author(s): Krishnan KJ, Turnbull DM
Publication type: Review
Publication status: Published
Journal: Essays in Biochemistry: Mitochondrial Function
Print publication date: 14/06/2010
ISSN (print): 0071-1365
ISSN (electronic): 1744-1358
Publisher: PORTLAND PRESS LTD