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Cerebrospinal fluid hypocretin levels are normal in idiopathic REM sleep behaviour disorder

Lookup NU author(s): Dr Kirstie Anderson


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Background: Rapid eye movement (REM) sleep behaviour disorder (RBD) is a common sleep disorder that can be associated with a number of neurodegenerative conditions as well as with narcolepsy. Current diagnostic criteria require overnight polysomnography, and there are no other biomarkers available. The control of REM sleep is complex with a putative on/off switch within the brainstem activated, amongst other things, by hypocretinergic pathways from the lateral hypothalamus. Methods: Cerebrospinal fluid hypocretin levels were measured in five patients with idiopathic RBD. Results: Hypocretin levels were between 254 and 450 pg/ml and therefore within the normal range of > 100 pg/ml. Conclusion: Hypocretin levels in patients with idiopathic RBD are normal.

Publication metadata

Author(s): Anderson KN, Vincent A, Smith IE, Shneerson JM

Publication type: Article

Publication status: Published

Journal: European Journal of Neurology

Year: 2010

Volume: 17

Issue: 8

Pages: 1105-1107

Print publication date: 01/08/2010

ISSN (print): 1351-5101

ISSN (electronic): 1468-1331

Publisher: Wiley-Blackwell Publishing Ltd.


DOI: 10.1111/j.1468-1331.2010.02954.x


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Funder referenceFunder name
G0401222Medical Research Council
G0501898Medical Research Council