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Lookup NU author(s): Dr Kirstie Anderson
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Background: Rapid eye movement (REM) sleep behaviour disorder (RBD) is a common sleep disorder that can be associated with a number of neurodegenerative conditions as well as with narcolepsy. Current diagnostic criteria require overnight polysomnography, and there are no other biomarkers available. The control of REM sleep is complex with a putative on/off switch within the brainstem activated, amongst other things, by hypocretinergic pathways from the lateral hypothalamus. Methods: Cerebrospinal fluid hypocretin levels were measured in five patients with idiopathic RBD. Results: Hypocretin levels were between 254 and 450 pg/ml and therefore within the normal range of > 100 pg/ml. Conclusion: Hypocretin levels in patients with idiopathic RBD are normal.
Author(s): Anderson KN, Vincent A, Smith IE, Shneerson JM
Publication type: Article
Publication status: Published
Journal: European Journal of Neurology
Print publication date: 01/08/2010
ISSN (print): 1351-5101
ISSN (electronic): 1468-1331
Publisher: Wiley-Blackwell Publishing Ltd.
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