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Lookup NU author(s): Dr Richard Temperley,
Dr Mateusz Wydro,
Professor Robert Lightowlers,
Professor Zofia Chrzanowska-Lightowlers
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The messenger RNAs containing the thirteen protein coding sequences of the human mitochondrial genome have frequently been regarded as a single functional category, alike in arrangement and hence in mode of expression. The "generic" mitochondrial mRNA is perceived as having (i) an arrangement within the polycistronic unit that permits its liberation following mt-tRNA processing, (ii) no 5' cap structure or introns, (iii) essentially no untranslated regions, and (iv) a poly(A) tail of approximately fifty nucleotides that is required in part to complete the termination codon. Closer inspection reveals that only two molecules fit this pattern. This article examines the extent to which human mitochondrial mRNA species differ from one another. (C) 2010 Elsevier B.V. All rights reserved.
Author(s): Temperley RJ, Wydro M, Lightowlers RN, Chrzanowska-Lightowlers ZM
Publication type: Review
Publication status: Published
Journal: Biochimica et Biophysica Acta (BBA) - Bioenergetics
Print publication date: 06/03/2010
ISSN (print): 0005-2728
ISSN (electronic): 0006-3002
Notes: Invited review presented at the 16th European Bioenergetics Conference, held in Warsaw, Poland on 17-22 July 2010.