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Human mitochondrial mRNAs - like members of all families, similar but different

Lookup NU author(s): Dr Richard Temperley, Dr Mateusz Wydro, Professor Robert Lightowlers, Professor Zofia Chrzanowska-Lightowlers

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Abstract

The messenger RNAs containing the thirteen protein coding sequences of the human mitochondrial genome have frequently been regarded as a single functional category, alike in arrangement and hence in mode of expression. The "generic" mitochondrial mRNA is perceived as having (i) an arrangement within the polycistronic unit that permits its liberation following mt-tRNA processing, (ii) no 5' cap structure or introns, (iii) essentially no untranslated regions, and (iv) a poly(A) tail of approximately fifty nucleotides that is required in part to complete the termination codon. Closer inspection reveals that only two molecules fit this pattern. This article examines the extent to which human mitochondrial mRNA species differ from one another. (C) 2010 Elsevier B.V. All rights reserved.


Publication metadata

Author(s): Temperley RJ, Wydro M, Lightowlers RN, Chrzanowska-Lightowlers ZM

Publication type: Review

Publication status: Published

Journal: Biochimica et Biophysica Acta (BBA) - Bioenergetics

Year: 2010

Volume: 1797

Issue: 6-7

Pages: 1081-1085

Print publication date: 06/03/2010

ISSN (print): 0005-2728

ISSN (electronic): 0006-3002

URL: http://dx.doi.org/10.1016/j.bbabio.2010.02.036

DOI: 10.1016/j.bbabio.2010.02.036

Notes: Invited review presented at the 16th European Bioenergetics Conference, held in Warsaw, Poland on 17-22 July 2010.


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