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Prostaglandin D-2 production in FM55 melanoma cells is regulated by alpha-melanocyte-stimulating hormone and is not related to melanin production

Lookup NU author(s): Professor Anthony Thody


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This study shows that prostaglandins in human FM55 melanoma cells and epidermal melanocytes are produced by COX-1. Prostaglandin production in FM55 melanoma cells was unrelated to that of melanin suggesting that the two processes can occur independently. alpha-Melanocyte-stimulating hormone, which had no effect on melanin production in FM55 cells, stimulated PGD(2) production in these cells without affecting PGE(2). While cAMP pathways may be involved in regulating PGD(2) production, our results suggest that alpha-MSH acts independently of cAMP, possibly by regulating the activity of lipocalin-type PGD synthase. This alpha-MSH-mediated effect may be associated with its role as an immune modulator.

Publication metadata

Author(s): Masoodi M, Nicolaou A, Gledhill K, Rhodes LE, Tobin DJ, Thody AJ

Publication type: Article

Publication status: Published

Journal: Experimental Dermatology

Year: 2010

Volume: 19

Issue: 8

Pages: 751-753

Print publication date: 01/08/2010

ISSN (print): 0906-6705

ISSN (electronic): 1600-0625

Publisher: Wiley-Blackwell Publishing Ltd.


DOI: 10.1111/j.1600-0625.2010.01098.x


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Funder referenceFunder name
NIHR Manchester Biomedical Research Centre
WT077714Wellcome Trust