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Lookup NU author(s): Professor Anthony Thody
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This study shows that prostaglandins in human FM55 melanoma cells and epidermal melanocytes are produced by COX-1. Prostaglandin production in FM55 melanoma cells was unrelated to that of melanin suggesting that the two processes can occur independently. alpha-Melanocyte-stimulating hormone, which had no effect on melanin production in FM55 cells, stimulated PGD(2) production in these cells without affecting PGE(2). While cAMP pathways may be involved in regulating PGD(2) production, our results suggest that alpha-MSH acts independently of cAMP, possibly by regulating the activity of lipocalin-type PGD synthase. This alpha-MSH-mediated effect may be associated with its role as an immune modulator.
Author(s): Masoodi M, Nicolaou A, Gledhill K, Rhodes LE, Tobin DJ, Thody AJ
Publication type: Article
Publication status: Published
Journal: Experimental Dermatology
Print publication date: 01/08/2010
ISSN (print): 0906-6705
ISSN (electronic): 1600-0625
Publisher: Wiley-Blackwell Publishing Ltd.
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