Toggle Main Menu Toggle Search

Open Access padlockePrints

Prolactin and smoking status in antipsychotic-treated patients

Lookup NU author(s): Dr Paul Mackin, Dr Amit Nulkar, Anthony Waton, Helen Watkinson


Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


Studies investigating the relationship between cigarette smoking and prolactin secretion in the general population have yielded inconsistent results. Many antipsychotic drugs increase prolactin secretion, but there are no published studies that have investigated the relationship between smoking and prolactinaemia in antipsychotic-treated patients. We obtained prolactin levels from 228 antipsychotic-treated patients in secondary care mental health services and investigated the relationship between prolactinaemia and cigarette smoking. Twenty-three percent (n = 52) of patients had hyperprolactinaemia. Patients prescribed typical or a combination of typical and atypical antipsychotics had a significantly higher prevalence of hyperprolactinaemia and higher mean prolactin concentration. Both current and ex-cigarette smokers had significantly lower mean prolactin levels and a lower prevalence of hyperprolactinaemia, but after controlling for potentially confounding variables, only current smoking status was a significant predictor of lower prolactin levels (OR 2.3, 95% CI 1.2 to 4.7, p = 0.002). In this preliminary, cross-sectional study, there was a robust statistical relationship between cigarette smoking and prolactinaemia. The mechanism(s) underpinning this association needs further investigation.

Publication metadata

Author(s): Mackin P, Nulkar A, Waton T, Watkinson HMO

Publication type: Article

Publication status: Published

Journal: Journal of Psychopharmacology

Year: 2011

Volume: 25

Issue: 5

Pages: 698-703

Print publication date: 10/08/2010

ISSN (print): 0269-8811

ISSN (electronic): 1461-7285

Publisher: Sage Publications Ltd.


DOI: 10.1177/0269881110379289

PubMed id: 20699354


Altmetrics provided by Altmetric


Funder referenceFunder name