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Clustered organization of cortical connectivity

Lookup NU author(s): Professor Marcus Kaiser


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Long-range corticocortical connectivity in mammalian brains possesses an intricate, nonrandom organization. Specifically, projections are arranged in ‘small-world’ networks, forming clusters of cortical areas, which are closely linked among each other, but less frequently with areas in other clusters. In order to delineate the structure of cortical clusters and identify their members, we developed a computational approach based on evolutionary optimization. In different compilations of connectivity data for the cat and macaque monkey brain, the algorithm identified a small number of clusters that broadly agreed with functional cortical subdivisions. We propose a simple spatial growth model for evolving clustered connectivity, and discuss structural and functional implications of the clustered, small-world organization of cortical networks.

Publication metadata

Author(s): Hilgetag CC, Kaiser M

Publication type: Article

Publication status: Published

Journal: Neuroinformatics

Year: 2004

Volume: 2

Issue: 3

Pages: 353-360

ISSN (print): 1539-2791

ISSN (electronic): 1559-0089

Publisher: Humana Press, Inc.


DOI: 10.1385/NI:2:3:353


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