Toggle Main Menu Toggle Search

Open Access padlockePrints

Gene duplication and hierarchical modularity in intracellular interaction networks

Lookup NU author(s): Dr Jennifer Hallinan


Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


Networks of interactions evolve in many different domains. They tend to have topological characteristics in common, possibly due to common factors in the way the networks grow and develop. It has been recently suggested that one such common characteristic is the presence of a hierarchically modular organization. In this paper, we describe a new algorithm for the detection and quantification of hierarchical modularity, and demonstrate that the yeast protein–protein interaction network does have a hierarchically modular organization.We further show that such organization is evident in artificial networks produced by computational evolution using a gene duplication operator, but not in those developing via preferential attachment of new nodes to highly connected existing nodes.

Publication metadata

Author(s): Hallinan J

Publication type: Article

Publication status: Published

Journal: BioSystems

Year: 2004

Volume: 74

Issue: 1-3

Pages: 51-62

ISSN (print): 0303-2647

ISSN (electronic): 1872-8324

Publisher: Elsevier


DOI: 10.1016/j.biosystems.2004.02.004


Altmetrics provided by Altmetric