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Cluster analysis of the p53 genetic regulatory network: Topology and biology

Lookup NU author(s): Dr Jennifer Hallinan

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Abstract

In this paper we describe a network module detection approach which combines a rapid and robust clustering algorithm with an objective measure of the coherence of the modules identified. The approach is applied to the network of genetic regulatory interactions surrounding the tumor suppressor gene p53. This algorithm identifies ten clusters in the p53 network, which are visually coherent and biologically plausible.

Publication metadata

Author(s): Hallinan JS

Publication type: Conference Proceedings (inc. Abstract)

Publication status: Published

Conference Name: IEEE Symposium on Computational Intelligence in Bioinformatics and Computational Biology (CIBCB)

Year of Conference: 2004

Pages: 1-8

Publisher: IEEE

URL: http://dx.doi.org/10.1109/CIBCB.2004.1393924

DOI: 10.1109/CIBCB.2004.1393924

Library holdings: Search Newcastle University Library for this item

ISBN: 0780387287

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