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Lookup NU author(s): Dr Julie Reichelt
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Here, we present strong evidence that the targeted deletion of keratin 10 (K10) alters sebocyte differentiation in mice, mediated by an increased proliferation and differentiation of cells located in the periphery of the glands. This was not accompanied by the induction of the proliferation-associated keratins K6, K16 and K17. Sebaceous gland cells of K10−/− mice showed an accelerated turnover and secreted more sebum including wax esters, triglycerides, and cholesterol esters. The levels of the major epidermal lipids ceramides and cholesterol were also increased, whereas glycosylceramides and sphingomyelin were decreased which was not based on altered sphingolipid biosynthesis. The amount of Cer(OS), covalently bound to the cornified envelope, remained unchanged, as well as the amount of loricrin and involucrin. In agreement with the unaltered expression of β-catenin and its targets cyclin D1 and c-Myc, we conclude that the altered composition of the suprabasal intermediate filament cytoskeleton in K10−/− mice increased the differentiation of epidermal stem cells towards the sebocyte lineage.
Author(s): Reichelt J, Breiden B, Sandhoff K, Magin TM
Publication type: Article
Publication status: Published
Journal: European Journal of Cell Biology
Year: 2004
Volume: 83
Issue: 11-12
Pages: 747-759
ISSN (print): 0171-9335
ISSN (electronic): 0724-5130
Publisher: Urban und Fischer Verlag
URL: http://dx.doi.org/10.1078/0171-9335-00429
DOI: 10.1078/0171-9335-00429
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