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A Grid-based System for Microbial Genome Comparison and Analysis

Lookup NU author(s): Dr Yudong Sun, Professor Anil Wipat, Dr Matthew Pocock, Professor Pete Lee, Professor Paul WatsonORCiD, Dr Keith Flanagan, James Worthington



Genome comparison and analysis can reveal the structures and functions of genome sequences of different species. As more genomes are sequenced, genomic data sources are increasing in size and availability such that their analysis is beyond the processing capabilities of most research institutes. The Grid is a powerful solution to support large-scale genomic data processing and genome analysis. This paper presents the Microbase project that is developing a Grid-based system for genome comparison and analysis, and discusses the first implementation of the system (called MicrobaseLite). MicrobaseLite uses a scalable computing environment to support computationally intensive microbial genome comparison and analysis, employing state-of-the-art technologies of Web Services, notification, comparative genomics and parallel computing. Microbase will support not only system-defined genome comparison and analysis but also user-defined, remotely conceived genome analysis.

Publication metadata

Author(s): Sun Y, Wipat A, Pocock M, Lee P, Watson P, Flanagan K, Worthington J

Publication type: Report

Publication status: Published

Series Title: School of Computing Science Technical Report Series

Year: 2004

Pages: 8

Print publication date: 01/12/2004

Source Publication Date: December 2004

Report Number: 881

Institution: School of Computing Science, University of Newcastle upon Tyne

Place Published: Newcastle upon Tyne