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Sequential immunohistochemical p53 expression in biopsies of oral lichen planus undergoing malignant evolution

Lookup NU author(s): Professor Marco Carrozzo


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Transformation in squamous cell carcinoma (SCC) may occur in a small percentage of patients affected by oral lichen planus (OLP), but the pathogenesis remains to be elucidated. Overexpression of p53 protein was investigated immunohistochemically in 28 cases of OLP, followed up by sequential biopsies for up to 96 months. In 15 cases (Group 1), no dysplastic changes or neoplastic transformation occurred during the follow-up period; in 7 cases, OLP and SCC were synchronously observed (Group 2), whereas in another 6 cases (Group 3) SCC developed several months or years after diagnosis of OLP. The percentage of p53-positive epithelial cells at first diagnosis was significantly higher in the cases of Groups 2 and 3 than in those of Group 1. In contrast, evaluation of growth fraction by MIB-1 monoclonal antibody did not show any statistical differences among the three groups. Although no conclusions can be drawn about the molecular pathway leading to neoplastic transformation of OLP, or about the role of p53, the results indicate that immunohistochemical evaluation of p53 expression may be a practical tool to select cases of OLP with a high risk of neoplastic transformation.

Publication metadata

Author(s): Carrozzo M; Valente G; Pagano M; Carbone M; Bobba V; Palestro G; Gandolfo S

Publication type: Article

Publication status: Published

Journal: Journal of Oral Pathology & Medicine

Year: 2001

Volume: 30

Issue: 3

Pages: 135-140

ISSN (print): 0904-2512

ISSN (electronic): 1600-0714

Publisher: Wiley-Blackwell Publishing Ltd.


DOI: 10.1034/j.1600-0714.2001.300302.x

Notes: Journal Article


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