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Genetic variation of CHRNA4 does not modulate attention in Parkinson's disease

Lookup NU author(s): Dr Gavin Hudson, Andrea Stutt, Professor Martin Eccles, Professor Dame Louise Robinson, Dr Liesl Allcock, Professor Patrick Chinnery, Professor David Burn

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Abstract

Parkinson's disease (PD) is a neurodegenerative disorder, characterised by cognitive decline and attentional impairment. Recently, variation in CHRNA4 (rs1044396) has been shown to affect visual and auditory function, affecting speed and attention, in healthy adults. An association between CHRNA4 variation and PD has not been shown. To determine the link between CHRNA4 variation and attentional deficit in PD. A genotype-phenotype correlation between the common CHRNA4:rs1044396 variant and several baseline parameters of attention was carried out in a large cohort of PD cases (n=222) and controls (n =159). We identified significant associations to measures of attention in PD patients compared to controls. However, we found no significant link to CHRNA4:rs1044396 genotypes to baseline attention variables in PD or in controls. We conclude that CHRNA4:rs1044396 genotypes do not significantly influence the attentional deficit found in PD patients. Contrary to previous studies, we also found no significant influence in healthy age-matched controls. (C) 2010 Elsevier Ireland Ltd. All rights reserved.


Publication metadata

Author(s): Hudson G, Stutt A, Eccles M, Robinson L, Allcock LM, Wesnes KA, Chinnery PF, Burn DJ

Publication type: Article

Publication status: Published

Journal: Neuroscience Letters

Year: 2010

Volume: 479

Issue: 2

Pages: 123-125

Print publication date: 01/07/2010

ISSN (print): 0304-3940

ISSN (electronic): 1872-7972

Publisher: Elsevier

DOI: 10.1016/j.neulet.2010.05.041


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