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Depressive behaviour in children diagnosed with a mitochondrial disorder

Lookup NU author(s): Professor Bobby McFarlandORCiD


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A higher incidence of depression has been described in adults with primary oxidative phosphorylation disease. We evaluated the psychological characteristics of eighteen non-retarded pediatric patients diagnosed with a disorder of the oxidative phosphorylation. We found significantly higher rate of withdrawn, depressive behaviour compared to population norm scores, to children with other types of inborn errors of metabolism and also in comparison to patients with Sotos syndrome. The occurrence of depressive behaviour showed no correlation with the degree of mitochondrial dysfunction. These findings support the hypothesis that mood disorders could be associated to abnormal cerebral energy metabolism. (C) 2010 Elsevier B.V. and Mitochondria Research Society. All rights reserved.

Publication metadata

Author(s): Morava E, Gardeitchik T, Kozicz T, de Boer L, Koene S, de Vries MC, McFarland R, Roobol T, Rodenburg RJT, Verhaak CM

Publication type: Article

Publication status: Published

Journal: Mitochondrion

Year: 2010

Volume: 10

Issue: 5

Pages: 528-533

Print publication date: 01/08/2010

ISSN (print): 1567-7249

ISSN (electronic): 1872-8278

Publisher: Elsevier


DOI: 10.1016/j.mito.2010.05.011


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Funder referenceFunder name
Tjallingh Roorda Foundation
864.05.008Nederlands Organization for Scientific Research NWO