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Human Laryngeal Ganglia Contain Both Sympathetic and Parasympathetic Cell Types

Lookup NU author(s): Professor Stephen McHanwell


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The presence of ganglia associated with the laryngeal nerves is well documented. In man, these ganglia have been less well studied than in other species and, in particular, the cell types within these ganglia are less well characterized. Using a panel of antibodies to a variety of markers found in the paraganglion cells of other species, we were able to show the existence of at least two populations of cells within human laryngeal paraganglia. One population contained chromogranin and tyrosine hydroxylase representing a neurosecretory population possibly secreting dopamine. A second population of choline acetyltransferase positive cells would appear to have a putative parasympathetic function. Further work is needed to characterize these cell populations more fully before it will be possible to assign functions to these cell types but our results are consistent with the postulated functions of these ganglia as chemoreceptors, neurosecretory cells, and regulators of laryngeal mucus secretion. Clin. Anat. 23: 673-682, 2010. (C) 2010 Wiley-Liss, Inc.

Publication metadata

Author(s): Ibanez M, Valderrama-Canales FJ, Maranillo E, Vazquez T, Pascual-Font A, McHanwell S, Sanudo J

Publication type: Article

Publication status: Published

Journal: Clinical Anatomy

Year: 2010

Volume: 23

Issue: 6

Pages: 673-682

Print publication date: 01/09/2010

ISSN (print): 0897-3806

ISSN (electronic): 1098-2353

Publisher: Wiley-Blackwell


DOI: 10.1002/ca.20956


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Funder referenceFunder name
FIS 06/0276Ministerio de Sanidad