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Regulation of cyclin D1 gene expression

Lookup NU author(s): Professor Neil PerkinsORCiD


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Cyclin D1 is a key regulator of cell proliferation and its expression is subject to both transcriptional and post-transcriptional regulation. in different cellular contexts, different pathways assume a dominant role in regulating its expression, whereas their disregulation can contribute to overexpression of cyclin D1 in tumorigenesis. Here, we discuss the ability of the NF-kappa B (nuclear factor kappa B)/IKK [I kappa B (inhibitor of NF-kappa B) kinase] pathways to regulate cyclin D1 gene transcription and also consider the newly discovered role of the SNARP (SNIP1/SkIP-associated RNA processing) complex as a co-transcriptional regulator of cyclin D1 RNA stability.

Publication metadata

Author(s): Witzel II, Koh LF, Perkins ND

Publication type: Conference Proceedings (inc. Abstract)

Publication status: Published

Conference Name: Biochemical Society Transactions: 13th Tenovus Scotland Symposium - Gene Expression in Development and Disease

Year of Conference: 2010

Pages: 217-222

ISSN: 0300-5127

Publisher: Portland Press Ltd.


DOI: 10.1042/BST0380217

Notes: Online ISSN: 1470-8752