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Regulation of the ReIA (p65) transactivation domain

Lookup NU author(s): Professor Neil PerkinsORCiD

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Abstract

The RelA (p65) NF-κB (nuclear factor κB) subunit contains an extremely active C-terminal transcriptional activation domain, required for its cellular function. In the present article, we review our knowledge of this domain, its modifications and its known interacting proteins. Moreover, we discuss how analysis of its evolutionary conservation reveals distinct subdomains and conserved residues that might give insights into its regulation and function.

Publication metadata

Author(s): O'Shea JM, Perkins ND

Publication type: Article

Publication status: Published

Journal: Biochemical Society Transactions

Year: 2008

Volume: 36

Issue: 4

Pages: 603-608

ISSN (print): 0300-5127

ISSN (electronic): 1470-8752

Publisher: Portland Press Ltd.

URL: http://dx.doi.org/10.1042/BST0360603

DOI: 10.1042/BST0360603

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