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Lookup NU author(s): Professor Kenn Gerdes,
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In prokaryotes, DNA can be segregated by three different types of cytoskeletal filaments. The best-understood type of partitioning (par) locus encodes an actin homolog called ParM, which forms dynamically unstable filaments that push plasmids apart in a process reminiscent of mitosis. However, the most common type of par locus, which is present on many plasmids and most bacterial chromosomes, encodes a P loop ATPase (ParA) that distributes plasmids equidistant from one another on the bacterial nucleoid. A third type of par locus encodes a tubulin homolog (TubZ) that forms cytoskeletal filaments that move rapidly with treadmill dynamics.
Author(s): Gerdes K, Howard M, Szardenings F
Publication type: Article
Publication status: Published
Print publication date: 10/06/2010
ISSN (print): 0092-8674
ISSN (electronic): 1097-4172
Publisher: Cell Press
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