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The role of GLUK5-containing kainate receptors in entorhinal cortex gamma frequency oscillations

Lookup NU author(s): Professor Mark Cunningham

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Abstract

Using in vitro brain slices of hippocampus and cortex, neuronal oscillations in the frequency range of 30-80 Hz (gamma frequency oscillations) can be induced by a number of pharmacological manipulations. The most routinely used is the bath application of the broad-spectrum glutamate receptor agonist, kainic acid. In the hippocampus, work using transgenic kainate receptor knockout mice have revealed information about the specific subunit composition of the kainate receptor implicated in the generation and maintenance of the gamma frequency oscillation. However, there is a paucity of such detail regarding gamma frequency oscillation in the cortex. Using specific pharmacological agonists and antagonists for the kainate receptor, we have set out to examine the contribution of kainate receptor subtypes to gamma frequency oscillation in the entorhinal cortex. The findings presented demonstrate that in contrast to the hippocampus, kainate receptors containing the GLUK5 subunit are critically important for the generation and maintenance of gamma frequency oscillation in the entorhinal cortex. Future work will concentrate on determining the exact nature of the cellular expression of kainate receptors in the entorhinal cortex. Copyright © 2008 Heather L. Stanger et al.

Publication metadata

Author(s): Stanger HL, Alford R, Jane DE, Cunningham MO

Publication type: Article

Publication status: Published

Journal: Neural Plasticity

Year: 2008

Volume: 2008

Print publication date: 01/01/2008

ISSN (print): 1687-5443

ISSN (electronic):

Publisher: Hindawi Publishing Corporation

URL: http://dx.doi.org/10.1155/2008/401645

DOI: 10.1155/2008/401645

Notes: Article ID 401645 12 pages

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