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Origin, homeostasis and function of Langerhans cells and other langerin-expressing dendritic cells

Lookup NU author(s): Professor Matthew CollinORCiD


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Langerhans cells (LCs) are a specialized subset of dendritic cells (DCs) that populate the epidermal layer of the skin. Langerin is a lectin that serves as a valuable marker for LCs in mice and humans. In recent years, new mouse models have led to the identification of other langerin+ DC subsets that are not present in the epidermis, including a subset of DCs that is found in most non-lymphoid tissues. In this Review we describe new developments in the understanding of the biology of LCs and other langerin+ DCs and discuss the challenges that remain in identifying the role of different DC subsets in tissue immunity. © 2008 Macmillan Publishers Limited. All rights reserved.

Publication metadata

Author(s): Merad M, Ginhoux F, Collin M

Publication type: Review

Publication status: Published

Journal: Nature Reviews Immunology

Year: 2008

Volume: 8

Issue: 12

Pages: 935-947

ISSN (print): 1474-1733

ISSN (electronic): 1474-1741


DOI: 10.1038/nri2455

PubMed id: 19029989