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Lookup NU author(s): Professor Heinz Grunze
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Born C, Seitz N-N, Grunze H, Vieta E, Dittmann S, Seemüller F, Amann B. Preliminary results of a fine-grain analysis of mood swings and treatment modalities of bipolar I and II patients using the daily prospective life-chart-methodology.Objective: The study aimed to increase the knowledge about the detailed course differences between different forms of bipolar disorder. Method: Using the prospective life-chart-clinician version, we compared the fine-grain analysis of mood swings and treatment modalities of 18 bipolar II with 31 bipolar I patients. Results: During an observational period of a mean of 26 months we observed an increase of euthymic days, and a decrease of (sub)depressive and (hypo)manic days. Days in a (sub)depressed state were more frequent than days of (hypo)mania as well as days of subdepression or hypomania in comparison to days of full-blown depression or mania. Bipolar II patients showed an increase in hypomanic days receiving more frequently antidepressants. Bipolar I patients, with a decrease of manic days, were significantly taking more often mood stabilizers. Conclusion: Treatment in a specialized bipolar clinic improves the overall outcome, but bipolar II disorder seems to be still treated sub-optimally with a possible iatrogenic increase of hypomanic days. © 2009 John Wiley & Sons A/S.
Author(s): Born C, Seitz N, Grunze H, Vieta E, Dittmann S, Seemüller F, Amann B
Publication type: Article
Publication status: Published
Journal: Acta Psychiatrica Scandinavica
Year: 2009
Volume: 120
Issue: 6
Pages: 474-480
ISSN (print): 0001-690X
ISSN (electronic): 1600-0447
Publisher: Wiley-Blackwell Publishing, Inc.
URL: http://dx.doi.org/10.1111/j.1600-0447.2009.01412.x
DOI: 10.1111/j.1600-0447.2009.01412.x
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