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Angiotensin-converting enzyme, renin-angiotensin system and human performance

Lookup NU author(s): Dr David Woods


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The angiotensin-converting enzyme (ACE) I/D polymorphism is strongly associated with circulating ACE levels in European populations. Initial studies over 10 years ago suggested an association between the I-allele (associated with low circulating ACE activity) and elite endurance performance. Subsequent studies also then suggested an association of the D-allele (high circulating ACE) with power-oriented performance. Not all studies are concordant however. The published literature is beset with the problems attendant in interpreting population-association studies including case definition, adequate cohort size, selection bias and appropriate control groups. Notwithstanding this, a plethora of data has been published. This has been followed by various studies trying to elucidate a physiological mechanism for such an association. This chapter will review the available data regarding the ACE I/D polymorphism and human performance both at sea level and at high altitude. It will also evaluate any data pertaining to postulated mechanisms. Copyright © 2009 S. Karger AG, Basel.

Publication metadata

Author(s): Woods D

Editor(s): Collins, M

Publication type: Book Chapter

Publication status: Published

Book Title: Genetics and Sports

Year: 2009

Volume: 54

Pages: 72-87

Print publication date: 01/01/2009

Series Title: Medicine and Sports Science

Publisher: S. Karger AG

Place Published: Switzerland


DOI: 10.1159/000235697

Library holdings: Search Newcastle University Library for this item

ISBN: 9783805590273