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Lookup NU author(s): Dr Lena Palaniyappan,
Dr Lisa Insole,
Emeritus Professor Nicol Ferrier
Full text for this publication is not currently held within this repository. Alternative links are provided below where available.
Sequenced (stepped) treatment approaches are widely endorsed in the management of depression. Combining antidepressants is a recognised step for those failing to respond to monotherapy. Despite the limited evidence base, this strategy is widely used by clinicians in practice. Not every combination used clinically has a sound neuropharmacological rationale and the use of such combinations may increase the side-effect burden without any additional advantage to the patient. Efficacy of various antidepressant combinations along with the data on side-effect profile and toxicity of such combined treatments are reviewed here. The different combinations are considered by each class of antidepressant available in the UK.
Author(s): Palaniyappan L, Insole L, Ferrier I
Publication type: Review
Publication status: Published
Journal: Advances in Psychiatric Treatment
ISSN (print): 1355-5146
ISSN (electronic): 1472-1481