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Recognition of deaminated bases by archaeal family-B DNA polymerases

Lookup NU author(s): Professor Bernard Connolly


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Archaeal family-B DNA polymerases interact specifically with uracil and hypoxanthine, stalling replication on encountering these deaminated bases in DNA template strands. The present review describes X-ray structural data which elucidate the mechanism of read-ahead recognition of uracil and suggests how this is coupled to cessation of polymerization. The possible role of read-ahead recognition of uracil/ hypoxanthine in DNA repair is discussed, as is the observation that the feature appears to be limited to replicative polymerases of the archaeal domain. © The Authors Journal compilation © 2009 Biochemical Society.

Publication metadata

Author(s): Connolly B

Publication type: Review

Publication status: Published

Journal: Biochemical Society Transactions

Year: 2009

Volume: 37

Issue: 1

Pages: 65-68

ISSN (print): 0300-5127

ISSN (electronic): 1470-8752


DOI: 10.1042/BST0370065

PubMed id: 19143603