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Lookup NU author(s): Professor Marco Carrozzo
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Oral lichen planus (OLP) is a relatively common chronic inflammatory disorder with a low risk of associated malignancy. A genetic predisposition linked to Th1 cytokine polymorphisms may predispose to the T-cell-mediated immunological response to an induced antigenic change that is supposed to cause OLP lesions. Amalgam restorations, hepatitis C virus and systemic medications may be etiologic factors. Topical immunomodulators such as powerful corticosteroids and calcineurin inhibitors may control OLP lesions, but their long-term effects need to be better explored and understood. Current therapeutic data are probably still insufficient to make recommendations with regard to the specific dosage, formulation mode of delivery or length of the therapy. © 2009 Expert Reviews Ltd.
Author(s): Carrozzo M, Thorpe R
Publication type: Review
Publication status: Published
Journal: Expert Review of Dermatology
ISSN (print): 1746-9872
ISSN (electronic): 1746-9880