Toggle Main Menu Toggle Search

Open Access padlockePrints

Peritoneal cooling may provide improved protection for uncontrolled donors after cardiac death

Lookup NU author(s): Susan Stamp, David Talbot


Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


Uncontrolled donation after cardiac death (DCD) renal transplantation relies on rapid establishment of organ preservation interventions. We have developed a model of the uncontrolled DCD, comparing current in situ perfusion (ISP) techniques with additional peritoneal cooling (PC). Ten pigs were killed and subjected to a 2 h ischemia period. The ISP group modeled current DCD protocols. The PC group (PC) modeled current protocols plus PC. Two animals were used as controls and subjected to 2 h of warm ischemia. Core renal temperature and microdialysis markers of ischemia were measured. Preservation interventions began at 30 min, with rapid laparotomy and kidney recovery performed at 2 h, prior to machine perfusion viability testing. The final mean renal temperature achieved in the ISP group was 26.3°C versus 16.9°C in the PC group (p = 0.0001). A significant cryopreservation benefit was suggested by lower peak microdialysate lactate and glycerol levels (ISP vs. PC, p = 0.0003 and 0.0008), and the superiority of the PC group viability criteria (p = 0.0147). This pilot study has demonstrated significant temperature, ischemia protection and viability assessment benefits with the use of supplementary PC. The data suggests a need for further research to determine the potential for reductions in the rates of ischemia-related clinical phenomena for uncontrolled DCDs. © 2009 The American Society of Transplantation and the American Society of Transplant Surgeons.

Publication metadata

Author(s): Navarro A, Asher J, Sohrabi S, Reddy M, Stamp S, Carter N, Talbot D

Publication type: Article

Publication status: Published

Journal: American Journal of Transplantation

Year: 2009

Volume: 9

Issue: 6

Pages: 1317-1323

ISSN (print): 1600-6135

ISSN (electronic): 1600-6143

Publisher: Wiley-Blackwell


DOI: 10.1111/j.1600-6143.2009.02633.x


Altmetrics provided by Altmetric